Amorphous alloy catalytic hydrogenation method to prepare indole-2-carboxylic acid

Using o-nitrotoluene and diethyl oxalate as starting materials, the ethanol alkaline solution of ethyl o-nitrophenylpyruvate was synthesized, and then the indole-2-carboxylic acid was synthesized by catalytic hydrogenation at 60~70 °C and 1.5MPa pressure with a total yield of > 70% (calculated by o-nitrotoluene), and the compound was identified by melting point, NMR, GC-MS spectra. The synthesis of indole-2-carboxylic acid by amorphous catalytic hydrogenation method has low cost, good activity, simple post-treatment and no environmental pollution.



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Reni nickel catalyst science knowledge(1)

Physical and chemical properties: Reni nickel catalyst before activation is silver-gray amorphous powder (nickel-aluminum alloy powder), with a moderate degree of flammability, partial activation in the presence of water and the production of hydrogen easy agglomeration, long-term exposure to air is easy to weather. Nickel-aluminum alloy powder is activated into gray-black particles, accompanied by active hydrogen, extremely unstable, oxidative combustion in the air, must be immersed in water or ethanol for preservation. It was first used by American engineer Murray Rainey as a catalyst in the hydrogenation of vegetable oils. The preparation process is to treat nickel-aluminum alloy with concentrated sodium hydroxide solution, in this process, most of the aluminum will react with sodium hydroxide and dissolve, leaving a lot of micropores of different sizes. In this way, the surface of Raininickel is a fine gray powder, but from a microscopic point of view, each tiny particle in the powder is a three-dimensional porous structure, this porous structure greatly increases its surface area, and the large surface area brings high catalytic activity, which makes Raininickel widely used as a heterogeneous catalyst in organic synthesis and industrial hydrogenation reactions. Since "Rainey" is a registered trademark of Grace Chemicals, strictly speaking, only products manufactured by the company's Davidson Chemical Division can be called "Lanny Nickel". The term "metal backbone catalyst" or "sponge-metal catalyst" is used to refer to catalysts with a microporous structure and physical and chemical properties similar to Raney nickel.