Maleic anhydride hydrogenation to prepare succinic anhydride


Succinic anhydride is a white, light yellow or light gray granular crystal, is the raw material of the organic synthesis industry, hydrogenation can obtain γ-butyrolipid, continue hydrogenation can obtain 1,4-butanediol and tetrahydrofuran, it is an intermediate in the pharmaceutical industry, easy to manufacture fenbufen, gastric ketone and succinsulfathiazole and other drugs.
    
The conditions for the hydrogenation of maleic anhydride in one step are: hydrogenation pressure 1~1.6 MPa, reaction temperature 50~100 °C, reaction time 1~2 h, the dosage of skeleton nickel catalyst is 4%~6% of maleic anhydride dosage, stirring speed 300 r/m in, under this condition, the highest yield of succinic anhydride can reach more than 90%.

 

 

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Reni nickel catalyst science knowledge(1)

Physical and chemical properties: Reni nickel catalyst before activation is silver-gray amorphous powder (nickel-aluminum alloy powder), with a moderate degree of flammability, partial activation in the presence of water and the production of hydrogen easy agglomeration, long-term exposure to air is easy to weather. Nickel-aluminum alloy powder is activated into gray-black particles, accompanied by active hydrogen, extremely unstable, oxidative combustion in the air, must be immersed in water or ethanol for preservation. It was first used by American engineer Murray Rainey as a catalyst in the hydrogenation of vegetable oils. The preparation process is to treat nickel-aluminum alloy with concentrated sodium hydroxide solution, in this process, most of the aluminum will react with sodium hydroxide and dissolve, leaving a lot of micropores of different sizes. In this way, the surface of Raininickel is a fine gray powder, but from a microscopic point of view, each tiny particle in the powder is a three-dimensional porous structure, this porous structure greatly increases its surface area, and the large surface area brings high catalytic activity, which makes Raininickel widely used as a heterogeneous catalyst in organic synthesis and industrial hydrogenation reactions. Since "Rainey" is a registered trademark of Grace Chemicals, strictly speaking, only products manufactured by the company's Davidson Chemical Division can be called "Lanny Nickel". The term "metal backbone catalyst" or "sponge-metal catalyst" is used to refer to catalysts with a microporous structure and physical and chemical properties similar to Raney nickel.