Application of ZL-N311 in the production of phenylethylamine hydrogenation to phenethylamine


The optical isomer of α-phenethylamine can be used as an alkaline splitter for the separation of acidic racemates. α-Phenethylamine is an important intermediate in the preparation of fine chemicals, and its derivatives are widely used in the field of pharmaceutical and chemical industry, mainly used in the synthesis of pharmaceuticals, dyes, fragrance emulsifiers, etc.
  
Cis-propylene phosphoric acid and (±)-a-phenylethylamine are formed into salts, epoxidized, and separated to obtain fosfomycin. Pure (±)-α-phenethylamine is a colorless liquid with a boiling point of 187.4 °C and a refractive index of 1.5260.
  
Aldehydes and ketones react with formic acid and ammonia (or primary and secondary amines), or with formamide to undergo a reductive amination reaction, called the Leuchart reaction. The selection of appropriate amines (or ammonia) can synthesize primary, secondary and tertiary amines. In the reaction, ammonia first undergoes nucleophilic addition with the carbonyl group, and then dehydrates to form imine, which is then reduced to produce amine.
  
Industry uses acetophenone with formic acid and liquid ammonia in the hydrogenation of Raini nickel to obtain racemate (±)-α-phenylethylamine.
  
It has been confirmed by the industrial application of many domestic phenylethylamine intermediate manufacturers, and the use of amorphous alloy catalyst ZL-N311 (ZL-2) to replace Raini nickel has faster hydrogenation speed, shortens the production cycle, stable catalytic activity, high cost performance of the product, and can further improve economic benefits.
  
Through the actual production comparison, it is verified that the use of amorphous alloy catalyst in a single hydrogenation can improve the yield by 1-2% compared with the traditional Reni nickel catalyst.

 

 

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Reni nickel catalyst science knowledge(1)

Physical and chemical properties: Reni nickel catalyst before activation is silver-gray amorphous powder (nickel-aluminum alloy powder), with a moderate degree of flammability, partial activation in the presence of water and the production of hydrogen easy agglomeration, long-term exposure to air is easy to weather. Nickel-aluminum alloy powder is activated into gray-black particles, accompanied by active hydrogen, extremely unstable, oxidative combustion in the air, must be immersed in water or ethanol for preservation. It was first used by American engineer Murray Rainey as a catalyst in the hydrogenation of vegetable oils. The preparation process is to treat nickel-aluminum alloy with concentrated sodium hydroxide solution, in this process, most of the aluminum will react with sodium hydroxide and dissolve, leaving a lot of micropores of different sizes. In this way, the surface of Raininickel is a fine gray powder, but from a microscopic point of view, each tiny particle in the powder is a three-dimensional porous structure, this porous structure greatly increases its surface area, and the large surface area brings high catalytic activity, which makes Raininickel widely used as a heterogeneous catalyst in organic synthesis and industrial hydrogenation reactions. Since "Rainey" is a registered trademark of Grace Chemicals, strictly speaking, only products manufactured by the company's Davidson Chemical Division can be called "Lanny Nickel". The term "metal backbone catalyst" or "sponge-metal catalyst" is used to refer to catalysts with a microporous structure and physical and chemical properties similar to Raney nickel.