Application of hydrogenation of intermediates in the pharmaceutical industry


Several drug intermediates were prepared by hydrogenation of SRNA-4 amorphous hydrogenation catalyst, and compared with Raney Ni, it was proved that SRNA series catalysts were 1-3 times the hydrogenation activity of Raney Ni, which could reduce catalyst consumption by more than 30%.
 

Hydrogenation effect of several drug intermediates

Reactant

Reaction conditions

Solvent

Catalyst single consumption g/kg

Temperature/℃
T/℃

Pressure/Mpa
P/Mpa

Time/h
t/h

SRNA

Traditional skeleton nickel
Raney Ni

Resorcinol

< 50

9

2

H2O

50

100

2,5-Dimethoxydihydrofuran

30

1

3

H2O

25

70

Fluoroazinic acid

80

4

4

H2O

300

500

Nitrobianoinamide

30-50

7

4

C2H5OH

90

200

Phenylacetonitrile

80-120

8

3

--

70

100

 

 

Related news


Reni nickel catalyst science knowledge(1)

Physical and chemical properties: Reni nickel catalyst before activation is silver-gray amorphous powder (nickel-aluminum alloy powder), with a moderate degree of flammability, partial activation in the presence of water and the production of hydrogen easy agglomeration, long-term exposure to air is easy to weather. Nickel-aluminum alloy powder is activated into gray-black particles, accompanied by active hydrogen, extremely unstable, oxidative combustion in the air, must be immersed in water or ethanol for preservation. It was first used by American engineer Murray Rainey as a catalyst in the hydrogenation of vegetable oils. The preparation process is to treat nickel-aluminum alloy with concentrated sodium hydroxide solution, in this process, most of the aluminum will react with sodium hydroxide and dissolve, leaving a lot of micropores of different sizes. In this way, the surface of Raininickel is a fine gray powder, but from a microscopic point of view, each tiny particle in the powder is a three-dimensional porous structure, this porous structure greatly increases its surface area, and the large surface area brings high catalytic activity, which makes Raininickel widely used as a heterogeneous catalyst in organic synthesis and industrial hydrogenation reactions. Since "Rainey" is a registered trademark of Grace Chemicals, strictly speaking, only products manufactured by the company's Davidson Chemical Division can be called "Lanny Nickel". The term "metal backbone catalyst" or "sponge-metal catalyst" is used to refer to catalysts with a microporous structure and physical and chemical properties similar to Raney nickel.